Endocrine-disrupting chemicals may impair bone health in male teens


Date:
May 3, 2022
Source:
The Endocrine Society
Summary:
Per- and polyfluoroalkyl substances (PFAS) and phthalates (two
types of endocrine-disrupting chemicals) may be associated with
lower bone mineral density in male teens, according to a new study.



FULL STORY ==========================================================================
Per- and polyfluoroalkyl substances (PFAS) and phthalates (two types
of endocrine-disrupting chemicals) may be associated with lower bone
mineral density in male teens, according to a new study published in
the Endocrine Society's Journal of Clinical Endocrinology and Metabolism.


========================================================================== Endocrine-disrupting chemicals are chemicals or mixtures of chemicals that interfere with the way the body's hormones work. Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals used in nonstick cookware,
clothing and food packaging, and are increasingly being found in
U.S. water supplies.

Phthalates are used in personal care products, food processing and
children's toys.

"Adolescence is an important time when our bodies build up bone. Almost
all U.S. children and adolescents are exposed to PFAS and phthalates, but
few studies have looked at how these chemicals could be impacting our bone health," said Abby F. Fleisch, M.D., M.P.H., of the Maine Medical Center Research Institute and Maine Medical Center in Portland, Maine. "Our
research found an association between certain PFAS and phthalates and
reduced bone mineral density in adolescent males. Because bone accrual primarily occurs during adolescence, if replicated, this finding may have implications for lifelong bone health." The researchers leveraged urine
and blood samples from 453 boys and 395 girls from the National Health
and Nutrition Examination Survey (NHANES) and found higher levels of
PFAS and phthalates may be associated with lower bone mineral density in adolescent males. The researchers did not find the same effect in girls.

Other authors of this study include: Jenny L. Carwile, Shravanthi
M. Seshasayee and Clifford J. Rosen of the Maine Medical Center Research Institute; Katherine A. Ahrens of the University of Southern Maine in
Portland, Maine; Russ Hauser of the Harvard T. H. Chan School of Public
Health in Boston, Mass.; Jeffrey B.

Driban of the Tufts Medical Center in Boston, Mass.; and Catherine
M. Gordon of the Texas Children's Hospital and Baylor College of Medicine
in Houston, Texas.

The study received funding from the National Institute of Environmental
Health Sciences.


========================================================================== Story Source: Materials provided by The_Endocrine_Society. Note: Content
may be edited for style and length.


========================================================================== Journal Reference:
1. Jenny L Carwile et al. Serum PFAS and Urinary Phthalate Biomarker
Concentrations and Bone Mineral Density in 12-19 Year Olds:
2011-2016 NHANES. JCEM, 2022 DOI: 10.1210/clinem/dgac228 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/05/220503091558.htm

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