• Blow flies can be used detect use of che

    From ScienceDaily@1:317/3 to All on Thursday, March 24, 2022 22:30:42
    Blow flies can be used detect use of chemical weapons, other pollutants


    Date:
    March 24, 2022
    Source:
    Indiana University
    Summary:
    A study suggests blow flies could be used to detect the use of
    chemical weapons -- as well as other dangerous substances --
    in areas too dangerous or remote for human investigators.



    FULL STORY ========================================================================== Researchers at the School of Science at IUPUI have found that blow flies
    can be used as chemical sensors, with a particular focus on the detection
    of chemical warfare agents.


    ========================================================================== Despite widespread bans, chemical weapons have been deployed in recent conflicts such as the Syrian civil war, and some experts fear they may be
    used in the war in Ukraine. An IUPUI study shows that blow flies could be
    used as a safer alternative for investigating the use of these weapons --
    as well as other chemicals in the environment -- keeping humans out of potentially dangerous situations.

    The work appears in the journal Environmental Science and Technology. The research was funded through a grant from the U.S. Defense Advanced
    Research Projects Agency.

    "Blow flies are ubiquitous, and they are very adept at sampling the
    environment around us," said Christine Picard, an associate professor of biology and director of the Forensic and Investigative Sciences Program in
    the School of Science at IUPUI. "They will fly through the environment,
    taste it, and that information will be stored in their guts. Through a
    series of experiments, we were able to look at how different environmental factors would impact their detection of chemical weapon simulants."
    "We used a mass spectrometer to determine what chemicals were in the blow flies' guts," Manicke said. "We were able to detect the chemical warfare
    agent simulants, and also some of the things chemical agents get broken
    down into once they're in the environment. If a fly were to come across
    a water source, with a chemical agent hydrolyzed in the water, we would
    find that in the fly." While chemical warfare agents do not persist for
    long in the environment, the researchers found they're preserved well
    enough in the fly's guts for chemical analysis. They also were able to
    detect the chemical warfare agent simulants up to 14 days after a fly's
    initial exposure -- illustrating a safer alternative for the collection
    of samples, without risking human lives.



    ==========================================================================
    "If an area is too dangerous, too remote or in an access-restricted area
    -- or if one just wanted to collect samples covertly -- then one just
    needs to put out some bait and the flies will come to the bait," Manicke
    said. "We can scan through big areas by drawing the flies into a trap
    and analyzing what is in their guts." This research also has important applications for environmental scientists who want to understand how pollutants, such as pesticides, move through the environment.

    "Due to the collaboration between Dr. Manicke and Dr. Picard, we were
    able to work on a project with the potential to make a direct impact,"
    said Sarah Dowling, a Ph.D. student who co-authored the study. "It
    is fulfilling to know that the work we did throughout this project
    could improve the safety of warfighters and others who deal with
    chemicals in the environment." The team of students who conducted the experiments using a chemical weapon simulant were led by Nick Manicke,
    an associate professor of chemistry and chemical biology and of forensic
    and investigative sciences at IUPUI. A chemical weapon simulant shares
    features of actual chemical warfare agents - - but is not poisonous to
    people -- as well as pesticides, which are chemically similar to chemical warfare agents in the terms of their molecules' behavior.

    Next, the researchers plan to apply what they learned from this study
    toward a new two-year project funded by the Army Research Office
    on Environmental Chemistry. This work will focus on the detection of
    molecules from "insensitive munitions," which are a new type of explosive compounds that are less likely to detonate by accident. Because of this, however, they tend to deposit more in the environment.

    Using blow flies from areas that are remote or dangerous, Manicke and
    Picard will look for traces of insensitive munition compounds in the
    flies, indicating environmental contamination.

    Additional contributors to the study include IUPUI Ph.D. students
    Christine Skaggs and Khadija Moctar and Charity Owings, a postdoctoral researcher at the University of Tennessee Knoxville, who was a
    Ph.D. student at IUPUI at the time of the study.


    ========================================================================== Story Source: Materials provided by Indiana_University. Note: Content
    may be edited for style and length.


    ========================================================================== Journal Reference:
    1. Sarah N. Dowling, Christine L. Skaggs, Charity G. Owings, Khadija
    Moctar,
    Christine J. Picard, Nicholas E. Manicke. Insects as
    Chemical Sensors: Detection of Chemical Warfare Agent
    Simulants and Hydrolysis Products in the Blow Fly Using
    LC-MS/MS. Environmental Science & Technology, 2022; 56 (6): 3535
    DOI: 10.1021/acs.est.1c07381 ==========================================================================

    Link to news story: https://www.sciencedaily.com/releases/2022/03/220324130235.htm

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