Biodegradable implant could help doctors monitor brain chemistry
Date:
March 22, 2022
Source:
Penn State
Summary:
A wireless, biodegradable sensor could offer doctors a way to
monitor changes in brain chemistry without requiring a second
operation to remove the implant, according to an international
team of researchers.
FULL STORY ==========================================================================
A wireless, biodegradable sensor could offer doctors a way to monitor
changes in brain chemistry without requiring a second operation to remove
the implant, according to an international team of researchers.
==========================================================================
In a minimally invasive procedure on mice, the researchers inserted
a wireless, biodegradable device into the deep brain region of a
mouse. The device collected data on levels of dopamine, an important neurotransmitter, and other properties of the brain, such as pH levels, temperature and electrophysiology before harmlessly dissolving back into
the body.
Because dopamine is critical in many neural-related conditions, a
biodegradable sensor to detect the neurotransmitter could be used by
doctors for a range of treatments and operations.
"The direct measurement of dopamine can be very significant because of
the role that neurotransmitters play in a lot of neural related disease,"
said Larry Cheng, the Dorothy Quiggle Professor in Engineering and an
associate of the Institute for Computational and Data Sciences. "I
think people in the past have been looking at a lot of the other
parameters in form of temperature, or fever, or sweating, among
others. These related parameters can be very helpful when we don't have
the direct measurement, but if we can have the direct measurement of
this neurotransmitter at the target location, and in real time, that can
be certainly more direct and even more helpful, because information can sometimes be very challenging to infer based on those other parameters."
The silicon-based implant includes a semiconductor called two-dimensional transition metal dichalcogenides, or TMDCs, which are considered an
emerging class of materials increasingly used in nanoelectronics and nanophotonics applications. The ability for these atomically thin TMDCs
to be manipulated allowed the scientists to design the implant to be biodegradable yet maintain electrical and electrochemical performance.
To make this implantable, all of this equipment must be packed into a
probe that measured about 13 or 14 millimeters long, said Cheng. For perspective, the diameter of a regular strength aspirin is about 14 millimeters.
========================================================================== "That's really for the entire device, but, if we're talking about the
sensor, itself, that is even smaller," said Cheng, who is also a member
of the Materials Research Institute.
The team then tested the device by inserting the probe in a section of
the mouse's brain called the basal ganglia.
In a clinical setting, Cheng said patients would wear a headband or other
type of apparatus to relay the implant's signals to equipment that the
medical staff could the use to monitor the patients' condition.
According to the researchers, the main benefit of a biodegradable device
is that it would require no further surgeries -- which add risks to
recovery -- to remove the device.
"Currently, after full recovery, the device has to be removed, or there
will be just something inside we don't need to use," said Cheng. "So
that's why here, the device is designed to be biodegradable and after
a certain amount of time and after it has fulfilled its function, it
can safely dissolve. So, the patient won't need to have go through the
second surgery operation to remove the device.
==========================================================================
The sheer number of chemicals, materials and designs that could be used
to make this device required advanced computing techniques, according to
Cheng. He added that computers were used to simulate different chemicals
and bioengineering schemes to find the ideal materials and design to
detect and measure the target molecule, in this case, dopamine.
"We have to introduce the material to model the 2D material and the
dopamine and then you have to make sure they are stable," said Cheng. "So, we'll have to optimize the initial structure and then we further study
the interaction between the stabilized material and the dopamine."
Ultimately, the team hopes that the device will be used to help human
patients, but they expect that an immediate need might be for doctors
who are engaged in animal studies.
"Some of the potential treatment options may first be available in animal studies where the implant could help scientists initially evaluate how
a disease progresses, how a patient recovers from a treatment and how
effective that treatment is," said Cheng. "So, the implant can be very
helpful to simply use in an animal model to better investigate these questions." Future work could be aimed at creating a sensor that monitors other aspects of brain chemistry, beyond dopamine detection, Cheng said.
========================================================================== Story Source: Materials provided by Penn_State. Original written by Matt Swayne. Note: Content may be edited for style and length.
========================================================================== Journal Reference:
1. Seung Min Yang, Jae Hyung Shim, Hyun‐U Cho, Tae‐Min
Jang,
Gwan‐Jin Ko, Jeongeun Shim, Tae Hee Kim, Jia Zhu, Sangun
Park, Yoon Seok Kim, Su‐Yeon Joung, Jong Chan Choe,
Jeong‐Woong Shin, Joong Hoon Lee, Yu Min Kang, Huanyu Cheng,
Youngmee Jung, Chul‐Ho Lee, Dong Pyo Jang, Suk‐Won
Hwang. Hetero‐Integration of Silicon Nanomembranes with 2D
Materials for Bioresorbable, Wireless Neurochemical System. Advanced
Materials, 2022; 2108203 DOI: 10.1002/ adma.202108203 ==========================================================================
Link to news story:
https://www.sciencedaily.com/releases/2022/03/220322170528.htm
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