• risk for asthma and wheezing in school-a

    From ScienceDaily@1:317/3 to All on Friday, March 18, 2022 22:30:36
    risk for asthma and wheezing in school-age girls
    Study of over 3,000 children from six European countries examines
    possible effects of prenatal exposure to bisphenols on respiratory health in childhood

    Date:
    March 18, 2022
    Source:
    Barcelona Institute for Global Health (ISGlobal)
    Summary:
    An analysis of data from more than 3,000 mother-child pairs from six
    European countries indicates that prenatal exposure to bisphenol A
    may have negative effects on respiratory health in school-age girls.



    FULL STORY ==========================================================================
    An analysis of data from more than 3,000 mother-child pairs from six
    European countries indicates that prenatal exposure to bisphenol A may
    have negative effects on respiratory health in school-age girls. The
    results of a study led by the Barcelona Institute for Global Health
    (ISGlobal), an entity supported by the "la Caixa" Foundation, have just
    been published in the journal Environment International.


    ========================================================================== Bisphenols are chemical substances used in the manufacture of plastics
    and resins found in many consumer products, such as food cans, reusable
    bottles and toys. The most well-known is bisphenol A (BPA), a known
    endocrine disruptor used widely in the manufacture of food containers and
    the interior coatings of such recipients. The European Chemicals Agency
    (ECHA) included BPA on its list of substances of "very high concern"
    in 2017. Since then, some countries have limited its use, leading some manufacturers to replace BPA with other bisphenols.

    Since it is known that bisphenols are present in maternal milk and
    that they can cross the placental barrier, the aim of the authors of
    the study published today was to discover whether prenatal exposure to
    these chemical compounds is associated with respiratory health problems
    in later years. The authors studied urine samples taken during pregnancy
    from more than 3,000 women from six European countries (Spain, France,
    Greece, Norway, the Netherlands and the United Kingdom) collected between
    1999 and 2010 and data on the respiratory health of their offspring
    collected years later through questionnaires and spirometry.

    Analysis of the urine samples revealed a high prevalence of BPA, which
    was found in 90% of the samples. The other bisphenols studied were,
    however, less prevalent at the time these samples were collected:
    the Netherlands was the only country where a notable presence of other bisphenols was detected among the study participants (bisphenol F in 40%
    of the samples and bisphenol S in 70%). This finding was probably due
    to the early switch to replacements for bisphenol A in that country.

    The results of this study revealed an association in girls between concentrations of bisphenol A in maternal urine during pregnancy and an increased risk of asthma and wheezing at school age (a twofold increase
    in the concentration of bisphenol A was linked to a 13% higher risk of respiratory symptoms). This association was not, however, observed in
    boys or in the case of the other two bisphenols studied. Neither were
    any associations observed between prenatal bisphenol A exposure and lung function at school age.

    "Our results are in line with those of earlier studies, which have
    also reported that bisphenol A has a negative impact on respiratory
    health in childhood. We believe that the effect may be due the fact that bisphenols can cross the placental barrier and interfere with the child's respiratory and immune systems during the developmental phase," explains
    Alicia Abella'n, ISGlobal researcher and first author of the study.

    Talking about the differences observed between girls and boys, Maribel
    Casas, ISGlobal researcher and last author of the study, makes the point
    that "bisphenols are endocrine disruptors and can interfere with sex
    hormones. As our findings suggest, this may give rise to differences
    in the effects they have depending on the sex of the person exposed."
    The study included data from eight birth cohorts: BiB (United Kingdom),
    EDEN (France), Generation R (The Netherlands); INMA Guipuzkoa, INMA
    Sabadell and INMA Valencia (Spain); MoBa (Norway) and RHEA (Greece).


    ========================================================================== Story Source: Materials provided by Barcelona_Institute_for_Global_Health_(ISGlobal). Note: Content may be
    edited for style and length.


    ========================================================================== Journal Reference:
    1. Alicia Abellan, Sara M. Mensink-Bout, Raquel Garcia-Esteban, Andrea
    Beneito, Leda Chatzi, Talita Duarte-Salles, Mariana F. Fernandez,
    Judith Garcia-Aymerich, Berit Granum, Carmen In~iguez,
    Vincent W.V. Jaddoe, Kurunthachalam Kannan, Aitana Lertxundi,
    Maria-Jose Lopez-Espinosa, Claire Philippat, Amrit K. Sakhi,
    Susana Santos, Vale'rie Siroux, Jordi Sunyer, Leonardo Trasande,
    Marina Vafeiadi, Fernando Vela-Soria, Tiffany C. Yang, Carlos
    Zabaleta, Martine Vrijheid, Liesbeth Duijts, Maribel Casas. In
    utero exposure to bisphenols and asthma, wheeze, and lung function
    in school-age children: a prospective meta-analysis of 8 European
    birth cohorts. Environment International, 2022; 107178 DOI:
    10.1016/j.envint.2022.107178 ==========================================================================

    Link to news story: https://www.sciencedaily.com/releases/2022/03/220318080253.htm

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