New study reviews anti-cancer activity of sustained release capsaicin formulations

Date:
May 4, 2022
Source:
Marshall University Joan C. Edwards School of Medicine
Summary:
A study provides the first published in-depth description
of the anti- cancer activity of capsaicin sustained release
formulations. Capsaicin is naturally found in chili peppers and
is the agent that provides the hot and spicy taste when eating
chili peppers.



FULL STORY ==========================================================================
A study by a team of researchers at the Marshall University Joan
C. Edwards School of Medicine provides the first published in-depth
description of the anti-cancer activity of capsaicin sustained release formulations. Capsaicin is naturally found in chili peppers and is
the agent that provides the hot and spicy taste when eating chili
peppers. Sustained release formulation of capsaicin are being explored
for extended anti-cancer activity.


========================================================================== Recently published in Pharmacology & Therapeutics, a leading medical
review journal in the field of pharmacology, the article chronicles
the growth- suppressive activity of sustained release capsaicin drugs, including solid dispersion systems, liposomes, phospholipid complexes
and nanoparticles. This is the first publication to provide an in-depth description of the anti-cancer activity of capsaicin sustained release formulations. The research team was led by Associate Professor of
Biomedical Sciences Piyali Dasgupta, Ph.D., and Professor of Biomedical Sciences Monica Valentovic, Ph.D.

"This review article is the first to provide a comprehensive overview of capsaicin formulations in human cancer," said Dasgupta, corresponding
author on the publication. "Previous publications in the literature
only briefly address sustained release formulations of capsaicin."
The nutritional agent capsaicin displayed robust growth-inhibitory
activity in a diverse array of human cancers. However, the clinical applications of capsaicin as a viable anti-cancer agent were hindered
by three factors -- poor solubility, low bioavailability and spicy flavor.

"Oral use of capsaicin is associated with unfavorable side effects
such as stomach cramps, nausea, a burning sensation in the gut and gastrointestinal irritation," said Valentovic, a senior author on the publication. "A strategy to overcome these drawbacks is the development of different delivery systems, such as encapsulating capsaicin in long-acting sustained release drug delivery systems could allow for more consistent capsaicin levels that could be more efficient as anti-cancer agents."
In addition to Dasgupta and Valentovic, clinical faculty Maria T. Tirona,
M.D., Joshua Hess, M.D., and Paul Finch, M.D., contributed to the
publication as well as co-authors Stephen Richbart, Justin Merritt,
Ashley Cox, Emily Moles and Katie Brown.

This research was supported by the R15 Academic Research Enhancement
Award Grants from the National Institutes of Health (1R15CA161491-01A1, 2R15CA161491- 02, 2R15CA161491-03, R15AI151970-01 and1R15HL145573-01), the
West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)
grant (P20GM103434) as well as the National Science Foundation (SURE)
and West Virginia NASA State Grant Consortium.


========================================================================== Story Source: Materials provided by Marshall_University_Joan_C._Edwards_School_of_Medicine.

Note: Content may be edited for style and length.


========================================================================== Journal Reference:
1. Justin C. Merritt, Stephen D. Richbart, Emily G. Moles, Ashley
J. Cox,
Kathleen C. Brown, Sarah L. Miles, Paul T. Finch, Joshua
A. Hess, Maria T. Tirona, Monica A. Valentovic, Piyali
Dasgupta. Anti-cancer activity of sustained release capsaicin
formulations. Pharmacology & Therapeutics, 2022; 238: 108177 DOI:
10.1016/j.pharmthera.2022.108177 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/05/220504135629.htm

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