• Poor diet associated with increased diab

    From ScienceDaily@1:317/3 to All on Tuesday, April 26, 2022 22:30:46
    Poor diet associated with increased diabetes risk across all gradients
    of genetic risk
    A poor diet, irrespective of genetic risk factors, is associated with a
    30 percent increased risk of diabetes

    Date:
    April 26, 2022
    Source:
    PLOS
    Summary:
    Genetic risk factors and diet quality are independently associated
    with type 2 diabetes; a healthy diet is linked to lower diabetes
    risk across all levels of genetic risk. That's the conclusion of
    a study of more than 35,000 U.S. adults.



    FULL STORY ========================================================================== Genetic risk factors and diet quality are independently associated with
    type 2 diabetes; a healthy diet is linked to lower diabetes risk across
    all levels of genetic risk. That's the conclusion of a study of more than 35,000 US adults publishing April 26 in PLOS Medicineby Jordi Merino of Massachusetts General Hospital, US, and colleagues.


    ==========================================================================
    Both genetic and lifestyle factors are known to contribute to individual susceptibility to type 2 diabetes. Previous studies have shown that
    adherence to a healthy lifestyle is associated with reduced risk of type
    2 diabetes across genetic profiles, but whether genetic profiles, in part, interact with lifestyle factors was unclear. In the new study, researchers analyzed data from three extensive cohort studies, including 35,759
    U.S. health professionals followed for 902,386 person-years of follow-up.

    The team found that, irrespective of genetic risk, a low diet quality,
    as compared to high diet quality, was associated with a 30% increased
    risk of type 2 diabetes (Pinteraction=0.69). The relative risk of type
    2 diabetes was 1.29 (95% CI 1.25-1.32, P<0.001) per standard deviation
    increase in the global polygenic score -- one measure of genetic risk
    -- and was 1.13 (1.09-1.17, P<0.001) per 10-unit decrease in Alternate
    Healthy Eating Index, a measure of diet quality. The joint association
    of low diet quality and increased genetic risk was similar to the sum of
    the risk for each factor alone (Pinteraction =0.30), further supporting independent associations. That said, one limitation of the study was that
    the cohort sampling might not necessarily generalize to other populations.

    Merino adds, "This study provided evidence that the risk of type 2
    diabetes attributed to increased genetic risk and low diet quality is
    similar to the sum of the risks associated with each factor alone. Such knowledge could serve to inform and design future strategies to advance
    the prevention of diabetes."

    ========================================================================== Story Source: Materials provided by PLOS. Note: Content may be edited
    for style and length.


    ========================================================================== Journal Reference:
    1. Jordi Merino, Marta Guasch-Ferre', Jun Li, Wonil Chung, Yang Hu,
    Baoshan
    Ma, Yanping Li, Jae H. Kang, Peter Kraft, Liming Liang, Qi Sun,
    Paul W.

    Franks, JoAnn E. Manson, Walter C. Willet, Jose C. Florez, Frank
    B. Hu.

    Polygenic scores, diet quality, and type 2 diabetes risk: An
    observational study among 35,759 adults from 3 US cohorts. PLOS
    Medicine, 2022; 19 (4): e1003972 DOI: 10.1371/journal.pmed.1003972 ==========================================================================

    Link to news story: https://www.sciencedaily.com/releases/2022/04/220426153624.htm

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