• Extracellular vesicles offer new insight

    From ScienceDaily@1:317/3 to All on Thursday, April 21, 2022 22:30:48
    Extracellular vesicles offer new insights into treating endocrine
    disorders

    Date:
    April 21, 2022
    Source:
    The Endocrine Society
    Summary:
    A new statement describes the importance of extracellular vesicles
    as a new research target for understanding the causes of certain
    endocrine disorders such as cancer and diabetes and discovering
    new treatments for these disorders.



    FULL STORY ==========================================================================
    In a new Scientific Statement released today, the Endocrine Society
    describes the importance of extracellular vesicles as a new research
    target for understanding the causes of certain endocrine disorders such
    as cancer and diabetes and discovering new treatments for these disorders.


    ========================================================================== During the last decade, endocrine researchers have shown great interest
    in extracellular vesicles and their hormone-like role in cell-to-cell communication. The statement provides insight into the functions of extracellular vesicles, which are secreted from all cells into biological fluids and carry endocrine signals that allow interactions between cells
    and distant sites in the body.

    "We're really excited about this new area of research that can help us
    better understand how people develop common endocrine conditions such
    as diabetes, obesity and cancer," said Carlos Salomon Ph.D., D.Med.Sc.,
    M.Sc., B.Sc., Associate Professor of The University of Queensland in
    Brisbane, Australia.

    "The statement highlights the likely uses of extracellular vesicles
    in detecting and monitoring disease progression and their role as next-generation drug delivery vehicles." Extracellular vesicles can
    help researchers better understand how to diagnose endocrine-related
    conditions including cancer and predict its progression. The role of extracellular vesicles as a cancer biomarker may extend to predicting
    real-time response to therapy.

    Extracellular vesicles are also involved in understanding the cause and treatment of diabetes, obesity and heart disease. Recent studies have
    shown the potential of extracellular vesicles, particularly ones derived
    from stem cells, in treating diabetes. Research into the vesicles provides insights into the causes of insulin resistance and glucose intolerance
    in obesity.

    Extracellular vesicles play an important role in the development of
    heart disease and could be useful for predicting risk. They also serve
    as biomarkers for high blood pressure and could have a therapeutic and
    blood pressure- lowering role.

    "We hope this statement brings awareness to the significance of
    extracellular vesicles in endocrinology and encourages more research on
    their potential as biomarkers and therapeutics," Salomon said.

    Other authors of this statement are: Saumya Das of Massachusetts General Hospital and Harvard Medical School in Boston, Mass.; Uta Erdbru"gger
    of the University of Virginia in Charlottesville, Va.; Raghu Kalluri of
    the University of Texas MD Anderson Cancer Center in Houston, Texas; Sai
    Kiang Lim of the Institute of Molecular and Cell Biology in Singapore;
    Jerrold M. Olefsky of the University of California-San Diego in La
    Jolla, Calif.; Gregory E. Rice of Inoviq Limited in Australia; Susmita
    Sahoo of the Icahn School of Medicine at Mount Sinai in New York, N.Y.;
    W. Andy Tao of Purdue University in West Lafayette, Ind.; Pieter Vader
    of Utrecht University and UMC Utrecht in Utrecht, the Netherlands;
    Qun Wang of Shandong University in Jinan, China; and Alissa M.

    Weaver of Vanderbilt University School of Medicine and Vanderbilt
    University Medical Center in Nashville, Tenn.


    ========================================================================== Story Source: Materials provided by The_Endocrine_Society. Note: Content
    may be edited for style and length.


    ========================================================================== Journal Reference:
    1. Carlos Salomon, Saumya Das, Uta Erdbru"gger, Raghu Kalluri,
    Sai Kiang
    Lim, Jerrold M Olefsky, Gregory E Rice, Susmita Sahoo, W Andy Tao,
    Pieter Vader, Qun Wang, Alissa M Weaver. Extracellular Vesicles
    and Their Emerging Roles as Cellular Messengers in Endocrinology:
    An Endocrine Society Scientific Statement. Endocrine Reviews,
    2022; DOI: 10.1210/ endrev/bnac009 ==========================================================================

    Link to news story: https://www.sciencedaily.com/releases/2022/04/220421094145.htm

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