Extracellular vesicles offer new insights into treating endocrine
disorders
Date:
April 21, 2022
Source:
The Endocrine Society
Summary:
A new statement describes the importance of extracellular vesicles
as a new research target for understanding the causes of certain
endocrine disorders such as cancer and diabetes and discovering
new treatments for these disorders.
FULL STORY ==========================================================================
In a new Scientific Statement released today, the Endocrine Society
describes the importance of extracellular vesicles as a new research
target for understanding the causes of certain endocrine disorders such
as cancer and diabetes and discovering new treatments for these disorders.
========================================================================== During the last decade, endocrine researchers have shown great interest
in extracellular vesicles and their hormone-like role in cell-to-cell communication. The statement provides insight into the functions of extracellular vesicles, which are secreted from all cells into biological fluids and carry endocrine signals that allow interactions between cells
and distant sites in the body.
"We're really excited about this new area of research that can help us
better understand how people develop common endocrine conditions such
as diabetes, obesity and cancer," said Carlos Salomon Ph.D., D.Med.Sc.,
M.Sc., B.Sc., Associate Professor of The University of Queensland in
Brisbane, Australia.
"The statement highlights the likely uses of extracellular vesicles
in detecting and monitoring disease progression and their role as next-generation drug delivery vehicles." Extracellular vesicles can
help researchers better understand how to diagnose endocrine-related
conditions including cancer and predict its progression. The role of extracellular vesicles as a cancer biomarker may extend to predicting
real-time response to therapy.
Extracellular vesicles are also involved in understanding the cause and treatment of diabetes, obesity and heart disease. Recent studies have
shown the potential of extracellular vesicles, particularly ones derived
from stem cells, in treating diabetes. Research into the vesicles provides insights into the causes of insulin resistance and glucose intolerance
in obesity.
Extracellular vesicles play an important role in the development of
heart disease and could be useful for predicting risk. They also serve
as biomarkers for high blood pressure and could have a therapeutic and
blood pressure- lowering role.
"We hope this statement brings awareness to the significance of
extracellular vesicles in endocrinology and encourages more research on
their potential as biomarkers and therapeutics," Salomon said.
Other authors of this statement are: Saumya Das of Massachusetts General Hospital and Harvard Medical School in Boston, Mass.; Uta Erdbru"gger
of the University of Virginia in Charlottesville, Va.; Raghu Kalluri of
the University of Texas MD Anderson Cancer Center in Houston, Texas; Sai
Kiang Lim of the Institute of Molecular and Cell Biology in Singapore;
Jerrold M. Olefsky of the University of California-San Diego in La
Jolla, Calif.; Gregory E. Rice of Inoviq Limited in Australia; Susmita
Sahoo of the Icahn School of Medicine at Mount Sinai in New York, N.Y.;
W. Andy Tao of Purdue University in West Lafayette, Ind.; Pieter Vader
of Utrecht University and UMC Utrecht in Utrecht, the Netherlands;
Qun Wang of Shandong University in Jinan, China; and Alissa M.
Weaver of Vanderbilt University School of Medicine and Vanderbilt
University Medical Center in Nashville, Tenn.
========================================================================== Story Source: Materials provided by The_Endocrine_Society. Note: Content
may be edited for style and length.
========================================================================== Journal Reference:
1. Carlos Salomon, Saumya Das, Uta Erdbru"gger, Raghu Kalluri,
Sai Kiang
Lim, Jerrold M Olefsky, Gregory E Rice, Susmita Sahoo, W Andy Tao,
Pieter Vader, Qun Wang, Alissa M Weaver. Extracellular Vesicles
and Their Emerging Roles as Cellular Messengers in Endocrinology:
An Endocrine Society Scientific Statement. Endocrine Reviews,
2022; DOI: 10.1210/ endrev/bnac009 ==========================================================================
Link to news story:
https://www.sciencedaily.com/releases/2022/04/220421094145.htm
--- up 7 weeks, 3 days, 10 hours, 51 minutes
* Origin: -=> Castle Rock BBS <=- Now Husky HPT Powered! (1:317/3)