Tumors change their metabolism to spread more effectively
Date:
April 13, 2022
Source:
Weill Cornell Medicine
Summary:
Cancer cells can disrupt a metabolic pathway that breaks down fats
and proteins to boost the levels of a byproduct called methylmalonic
acid, thereby driving metastasis, according to new research. The
findings open a new lead for understanding how tumors metastasize,
or spread to other tissues, and hints at novel ways to block the
spread of cancer by targeting the process.
FULL STORY ========================================================================== Cancer cells can disrupt a metabolic pathway that breaks down fats and
proteins to boost the levels of a byproduct called methylmalonic acid,
thereby driving metastasis, according to research led by scientists at
Weill Cornell Medicine.
The findings open a new lead for understanding how tumors metastasize,
or spread to other tissues, and hints at novel ways to block the spread
of cancer by targeting the process.
==========================================================================
The new results, published March 31 in Nature Metabolism, show that
metastatic tumors suppress the activity of a key enzyme in propionate metabolism, the process by which cells digest certain fatty acids and
protein components.
Suppressing the enzyme increases production of methylmalonic acid
(MMA). That, in turn, causes the cells to become more aggressive and
invasive.
Cancer is the second leading cause of death worldwide, and metastasis
drives much of that mortality. Once a tumor begins to metastasize to
different tissues and organs around the body, it can quickly become
difficult or impossible to treat. However, researchers have made few
inroads in understanding how a tumor cell acquires the ability to
metastasize.
"A lot of work has been focused on primary tumor initiation and growth,
or examining the metastatic tumor, but to go from the primary tumor to the metastatic tumor, that transition has not been studied very extensively,"
said co-senior author Dr. John Blenis, the Anna-Maria and Stephen Kellen Professor in Cancer Research, professor of pharmacology and associate
director of basic science of the Sandra and Edward Meyer Cancer Center
at Weill Cornell Medicine.
To address that gap, Dr. Blenis and his colleagues have worked for several years to characterize the metabolic changes that cells undergo during the metastatic transition. That effort previously revealed that as people age, their bodies produce more serum MMA (although the source remains unknown),
and that higher MMA levels drive worse cancer outcomes. Healthy cells
also produce MMA, though, so in the new study Dr. Blenis's team probed
the metabolite's cancer-related activities more deeply.
"Cancer cells themselves can hijack the pathway that makes methylmalonic
acid and this forms a feed-forward cycle that drives cancer progression
towards more aggressive and more metastatic forms," said co-first
author Dr. Vivien Low, a postdoctoral fellow in Dr. Blenis's lab. The
other co-first authors Dr. Ana Gomes and Dr. Didem Ilter, were also postdoctoral fellows in the lab at the time of the study. Dr. Gomes is
now a faculty member and Dr. Ilter is a research scientist at H. Lee
Moffitt Cancer Center & Research Institute.
The discovery adds to a growing body of work showing that specific
products of metabolism, called oncometabolites, can drive many aspects
of cancer progression and metastasis.
While the new paper focused on various models of breast cancer, Dr. Low
said the team is now analyzing other types of cancer cells as well,
where they expect to find similar mechanisms operating. The scientists
are also searching for ways to attack the process.
"Metastasis is responsible for about 80 to 90 percent of cancer-related mortality, so if we can predict when someone has the potential to
develop metastatic tumors, or treat those metastatic tumors that might
have this pathway up-regulated, then we might have a very effective,
novel therapy," Dr.
Blenis said.
========================================================================== Story Source: Materials provided by Weill_Cornell_Medicine. Note:
Content may be edited for style and length.
========================================================================== Journal Reference:
1. Ana P. Gomes, Didem Ilter, Vivien Low, Stanislav Drapela, Tanya
Schild,
Edouard Mullarky, Julie Han, Ilaria Elia, Dorien Broekaert, Adam
Rosenzweig, Michal Nagiec, Joana B. Nunes, Bethany E. Schaffer,
Anders P.
Mutvei, John M. Asara, Lewis C. Cantley, Sarah-Maria Fendt,
John Blenis.
Altered propionate metabolism contributes to tumour
progression and aggressiveness. Nature Metabolism, 2022; DOI:
10.1038/s42255-022-00553-5 ==========================================================================
Link to news story:
https://www.sciencedaily.com/releases/2022/04/220413131215.htm
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